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  • Home
  • RFT R&D Department
    • About RFT R&D
    • Who's who
    • Resources
    • NIHR support
    • Library Support
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    • Red4Research 2024
  • Why research matters
    • Clinical research in the NHS
    • Why research is important
    • Evidence
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critical care


NIHR Portfolio Studies - open to recruitment:

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GenOMICC: Genetics of Susceptibility and Mortality in Critical Care
Principal Investigator: Prof. Anil Hormis
Sponsor: NHS Lothian / University of Edinburgh
GenOMICC is a, open, collaborative, global community of doctors and scientists trying to understand and treat critical illness. Our partners have been recruiting patients since 2016 to study emerging infections (SARS/MERS/Flu), sepsis, and other forms of critical illness. It is the largest study of its kind anywhere in the world.​
Open to Associate PI scheme
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MOSAICC
Principal Investigator: Prof. Anil Hormis
​Sponsor: University Hospitals of Derby and Burton NHS Foundation Trust
Evaluating the clinical and cost-effectiveness of IV 8.4% Sodium bicarbonate administration for critically ill patients with Acute Kidney Injury and metabolic acidosis.
Open to Associate PI scheme

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AIRWAYS-3
Principal Investigator: Prof. Anil Hormis
Sponsor: University Hospitals Bristol and Weston NHS Foundation Trust
The aim of the study is to find out whether insertion of a supraglottic airways device is more effective than tracheal intubation for adults who have suffered a cardiac arrest in hospital. 
Open to Associate PI scheme

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SHORTER Trial
Principal Investigator: Dr Susie Robinson
Sponsor: The Newcastle upon Tyne Hospitals NHS Foundation Trust
This study aims to determine whether short duration antibiotic therapy is non-inferior to standard of care in terms of mortality and reduces overall antibiotic exposure. 

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GuARDS
Principal Investigator: Prof. Anil Hormis
Sponsor: The University of Edinburgh & Lothian Health Board
What is the clinical and cost effectiveness of dexamethasone given early (within 72 hours of diagnosis) in acute respiratory distress syndrome (ARDS)?

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ABBRUPT
Principal Investigator: Dr Susie Robinson
Sponsor: University of Birmingham
This study will compare two commonly used treatments (beta blocker and amiodarone) for New Onset Atrial Fibrillation (NOAF) in intensive care. 
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OPTICAL
Principal Investigator: Dr Clare Windsor NOTE: We are acting as a Participant Identification Centre (PIC) for this study
Sponsor: University College London
For young people with complex health needs, moving from paediatric to adult intensive care can be a particularly vulnerable time, especially as there is not yet enough information on how to make this transition smoother.
​This study aims to provide the necessary research for the development of clearer guidelines on ICU transition, and hence improve the experiences of patients and their families. 

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​AWAKE PRONE
Principal Investigator: Professor Anil Hormis
Sponsor: University of Warwick
AWAKE PRONE is part of the Confederation of Respiratory Critical Care Trials (CoReCCT).
It will evaluate the effect of awake prone positioning on need for tracheal intubation. It will also evaluate the effect of awake prone positioning on mortality, length of hospital stay, length of critical care stay, health-related quality, time to tracheal intubation, need for non-invasive respiratory support, and duration of invasive mechanical ventilation.

nihr portfolio studies - in follow up:

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UK-ROX: Evaluating the Clinical and Cost-Effectiveness of a Conservative Approach to Oxygen Therapy for Invasively Ventilated Adults in Intensive Care​
Principal Investigator: Prof. Anil Hormis
Sponsor: Intensive Care National Audit & Research Centre 
'Around 184,000 critically ill adults are admitted to intensive care units (ICUs) each year in the UK. Over 30% of these will require help from a breathing machine (called a ventilator), often in combination with additional oxygen. As such, oxygen is the most common therapy used to treat patients admitted to an ICU, who require help from a ventilator. Despite this, we do not know how much oxygen to give to patients in order to optimise their recovery. ... Our aim is to find out whether keeping oxygen saturations at lower levels (conservative oxygen therapy) is better than the higher level that is currently being used in the NHS to treat patients in ICU needing help from a ventilator.'

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​iRehab
Principal Investigator: Cheryl Graham
Sponsor: Ulster University
This study will investigate, in survivors of critical illness following discharge from hospital after an Intensive Care Unit (ICU) admission, the effects of a six-week remote multicomponent rehabilitation intervention compared to standard care on health-related quality of life at eight weeks post-randomisation.

nihr portfolio studies - in set up:

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The VIP-3 Study
Principal Investigator: Professor Anil Hormis
Sponsor: St George's, University of London
This study will look at patients aged 75 and above admitted as an emergency to Intensive Care Units (ICU) 
The investigators will be looking at communication whilst these patients are on the ICU. In particular whether a family meeting takes place (to discuss progress and patient wishes) and if so what is discussed in the meeting.
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