Haematology

haematology

NIHR Portfolio Studies - open to recruitment:

RADAR (UK-MRA Myeloma XV)
Principal Investigator: Dr Arun Alfred
Sponsor: University of Leeds
Comparing treatment escalation and de-escalation strategies in newly diagnosed patients with multiple myeloma.

SECURE
Principal Investigator: Dr Arun Alfred
Co-investigators: Dr Kathryn Goddard, Dr James Taylor, Dr Joe Joseph
Sponsor: Oxford University Hospitals NHS Foundation Trust
This study aims to find out more about the role of family history and demographic factors in the development of MGUS (monoclonal gammopathy of undetermined significance). it will also find out more about the psychological impact of an MGUS diagnosis and individual quality of life.

PROPEL
Principal Investigator: Dr James Taylor
Sponsor: University of Warwickshire & University Hospitals Coventry and Warwickshire
This trial aims to establish the clinical impact and cost-effectiveness of best practice usual care compared to a multiphasic multimodal personalised prehabilitation care package on fatigue, emotional wellbeing and quality of life in patients in remission following induction chemotherapy.

nihr portfolio studies - in follow up:

FLAIR: A trial of ibrutinib with rituximab for chronic lymphocytic leukaemia
Principal Investigator: Dr Kathryn Goddard
Sponsor: University of Leeds
This trial is comparing ibrutinib alongside rituximab with fludarabine, cyclophosphamide, rituximab and venetoclax for chronic lymphocytic leukaemia. This trial is for people who haven’t yet had treatment for their chronic lymphocytic leukaemia (CLL).

STATIC: Intermittent vs Continuous treatment strategies in CLL
Principal Investigator: Dr Kathryn Goddard
Sponsor: University of Leeds
The primary aim of this study is to assess whether patients with Chronic Lymphocytic Leukaemia (CLL) on long-term treatment with BTK inhibitor (including ibrutinib) have similar disease control with an intermittent treatment strategy compared with standard continuous treatment.

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