GenOMICC Study Summary

anaesthetic & critical care studies summaries

Protocol v4.0 08/11/2023
Rotherham Principal Investigator: Professor Anil Hormis
Research team members: Cheryl Graham/Dr Katie Webb

research topic:

Genetic factors that determine susceptibility to critical illness.
Some of our critical care patients are invited to take part in GenOMICC, an observational blood/saliva sampling study to establish a prospective DNA resource for hypothesis-testing and genome-wide discovery of host genetic variants underlying susceptibility to severe infection, and outcome from life-threatening systemic injury.

inclusion criteria:

Critical illness (require continuous cardiovascular or respiratory monitoring or invasive mechanical ventilation) AND present with the following primary diagnoses:

COVID-19. Confirmed or suspected COVID-19.
Influenza. Confirmed or suspected infection with influenza virus.
Secondary pneumonia. Acute pneumonia complicating confirmed infection with influenza virus.
RSV. Confirmed infection with respiratory syncytial virus.
Cellulitis. Soft tissue infections causing systemic sepsis.
Pneumonia. Primary pneumonia of any aetiology, with radiographic changes at presentation to critical care. Pneumonia is defined as: symptoms and signs consistent with an acute lower respiratory tract infection associated with new radiographic shadowing for which there is no other explanation (eg, not pulmonary oedema or infarction). Where this illness is the primary reason for hospital admission and is managed as pneumonia, the patient is eligible for inclusion.(Harris et al, 2011) No microbiology information is required to meet this entry criterion
Pancreatitis. Pancreatitis of any aetiology.

exclusion criteria:

There are no exclusions to recruitment and no age restrictions. All consenting patients meeting the inclusion criteria will be included.

consent:

Formal consent is required for GenOMICC trial enrolment/sampling. If you think your patient is in any way eligible please contact the research team who will review the full inclusion/exclusion criteria and approach for consent.

This genome project has already published some results: