critical care studies summaries

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Protocol v4.0 08/11/2023
Rotherham Principal Investigator: Professor Anil Hormis


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research topic:

Observational sampling study

inclusion criteria:

Critical illness (require continuous cardiovascular or respiratory monitoring or invasive mechanical ventilation) AND present with the following primary diagnoses:

• COVID-19. Confirmed or suspected COVID-19.
• Influenza. Confirmed or suspected infection with influenza virus.
  
• Secondary pneumonia. Acute pneumonia complicating confirmed infection with influenza virus.
  
• RSV. Confirmed infection with respiratory syncytial virus.
  
• Cellulitis. Soft tissue infections causing systemic sepsis.
  
• Pneumonia. Primary pneumonia of any aetiology, with radiographic changes at presentation to critical care. Pneumonia is defined as: symptoms and signs consistent with an acute lower respiratory tract infection associated with new radiographic shadowing for which there is no other explanation (eg, not pulmonary oedema or infarction). Where this illness is the primary reason for hospital admission and is managed as pneumonia, the patient is eligible for inclusion.(Harris et al, 2011) No microbiology information is required to meet this entry criterion
  
• Pancreatitis. Pancreatitis of any aetiology.

exclusion criteria:

​There are no exclusions to recruitment and no age restrictions. All consenting patients meeting the inclusion criteria will be included.

consent:

Formal consent is required for the GenOMICC study. If you think your patient is in any way eligible please contact the research team (Cheryl 6060, Jake 7038, Dawn 6057) who will review the full inclusion criteria and approach for consent.